Assay Detail
Functional
CHEMBL5609198
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCC827 cells incubated for 48 hrs by CCK8 assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.76 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5612012 | — | — | 1 | 9.47 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.90 |
| CHEMBL444724 | — | — | 1 | 8.90 |
| CHEMBL5613733 | — | — | 1 | 8.81 |
| CHEMBL5612097 | — | — | 1 | 8.78 |
| CHEMBL5614173 | — | — | 1 | 8.76 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.65 |
| CHEMBL5614105 | — | — | 1 | 8.65 |
| CHEMBL5612471 | — | — | 1 | 8.33 |
| CHEMBL5613654 | — | — | 1 | 8.29 |
| CHEMBL5612409 | — | — | 1 | 8.07 |
| CHEMBL498221 | — | — | 1 | 8.04 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.03 |
| CHEMBL5613033 | — | — | 1 | 7.73 |
| CHEMBL5613720 | — | — | 1 | 7.70 |
| CHEMBL5612420 | — | — | 1 | 7.70 |
| CHEMBL5613474 | — | — | 1 | 7.68 |
| CHEMBL5613459 | — | — | 1 | 7.53 |
| CHEMBL5613006 | — | — | 1 | 7.50 |
| CHEMBL496792 | — | — | 1 | 7.31 |
| CHEMBL5612238 | — | — | 1 | 7.28 |
| CHEMBL5614335 | — | — | 1 | 7.27 |
| CHEMBL5614102 | — | — | 1 | 6.95 |
| CHEMBL5612491 | — | — | 1 | 6.89 |
| CHEMBL5612158 | — | — | 1 | 6.86 |
| CHEMBL5612419 | — | — | 1 | 6.65 |
| CHEMBL5612840 | — | — | 1 | 6.64 |
| CHEMBL5613227 | — | — | 1 | 6.51 |
| CHEMBL5613588 | — | — | 1 | 6.46 |
| CHEMBL5614263 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5612012 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.254 | nM | 8.90 |
| CHEMBL444724 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL5613733 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL5612097 | — | IC50 | = | 1.65 | nM | 8.78 |
| CHEMBL5614173 | — | IC50 | = | 1.74 | nM | 8.76 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL5614105 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL5612471 | — | IC50 | = | 4.64 | nM | 8.33 |
| CHEMBL5613654 | — | IC50 | = | 5.16 | nM | 8.29 |
| CHEMBL5612409 | — | IC50 | = | 8.55 | nM | 8.07 |
| CHEMBL498221 | — | IC50 | = | 9.02 | nM | 8.04 |
| CHEMBL107 | COLCHICINE | IC50 | = | 9.31 | nM | 8.03 |
| CHEMBL5613033 | — | IC50 | = | 18.59 | nM | 7.73 |
| CHEMBL5612420 | — | IC50 | = | 19.75 | nM | 7.70 |
| CHEMBL5613720 | — | IC50 | = | 19.84 | nM | 7.70 |
| CHEMBL5613474 | — | IC50 | = | 20.97 | nM | 7.68 |
| CHEMBL5613459 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL5613006 | — | IC50 | = | 31.81 | nM | 7.50 |
| CHEMBL496792 | — | IC50 | = | 49.19 | nM | 7.31 |
| CHEMBL5612238 | — | IC50 | = | 51.96 | nM | 7.28 |
| CHEMBL5614335 | — | IC50 | = | 53.97 | nM | 7.27 |
| CHEMBL5614102 | — | IC50 | = | 113.33 | nM | 6.95 |
| CHEMBL5612491 | — | IC50 | = | 130.13 | nM | 6.89 |
| CHEMBL5612158 | — | IC50 | = | 139.77 | nM | 6.86 |
| CHEMBL5612419 | — | IC50 | = | 224.73 | nM | 6.65 |
| CHEMBL5612840 | — | IC50 | = | 228.33 | nM | 6.64 |
| CHEMBL5613227 | — | IC50 | = | 307.53 | nM | 6.51 |
| CHEMBL5613588 | — | IC50 | = | 345.53 | nM | 6.46 |
| CHEMBL5614263 | — | IC50 | = | 431.1 | nM | 6.37 |
| CHEMBL5613201 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613893 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5614228 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5612770 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613592 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5612859 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613993 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5614199 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613032 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5612352 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5613904 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5614275 | — | IC50 | > | 1000.0 | nM | - |