Assay Detail
Functional
CHEMBL5609199
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Antiproliferative activity against Paclitaxel-resistant human A2780 cells incubated for 48 hrs by CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Paclitaxel-resistant A2780 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.37 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5612012 | — | — | 1 | 9.12 |
| CHEMBL5614173 | — | — | 1 | 8.65 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.30 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5612012 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL5614173 | — | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL107 | COLCHICINE | IC50 | = | 500.5 | nM | 6.30 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3818.0 | nM | 5.42 |