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Assay Detail

CHEMBL5609713

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Functional
Antiplasmodial activity against asexual blood stage of Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 72 hrs by LDH assay
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.
Calic PPS, Ashton TD, Mansouri M, Loi K, Jarman KE, Qiu D, Lehane AM, Roy S, Rao GP, Maity B, Wittlin S, Crespo B, Gamo FJ, Deni I, Fidock DA, Chowdury M, de Koning-Ward TF, Cowman AF, Jackson PF, Baud D, Brand S, Laleu B, Sleebs BE.
Eur J Med Chem (2024) 276 : 116677 -116677
PubMed 39024967 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 44 6.36 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5613291 — — 1 8.30
CHEMBL5612285 — — 1 7.82
CHEMBL5613620 — — 1 7.80
CHEMBL5612641 — — 1 7.72
CHEMBL5612724 — — 1 7.10
CHEMBL5612163 — — 1 6.91
CHEMBL5612025 — — 1 6.89
CHEMBL5613408 — — 1 6.89
CHEMBL5611999 — — 1 6.81
CHEMBL5612240 — — 1 6.79
CHEMBL5612287 — — 1 6.77
CHEMBL5612686 — — 1 6.74
CHEMBL5612132 — — 1 6.59
CHEMBL5613193 — — 1 6.58
CHEMBL5612722 — — 1 6.54
CHEMBL5613537 — — 1 6.51
CHEMBL5612135 — — 1 6.34
CHEMBL5614323 — — 1 6.33
CHEMBL5613878 — — 1 6.31
CHEMBL5614134 — — 1 6.26
CHEMBL5612162 — — 1 6.24
CHEMBL5614092 — — 1 6.20
CHEMBL581128 — — 1 6.17
CHEMBL5613594 — — 1 6.13
CHEMBL5613052 — — 1 6.07
CHEMBL5613130 — — 1 6.07
CHEMBL5614146 — — 1 6.07
CHEMBL5612661 — — 1 6.00
CHEMBL5611976 — — 1 5.98
CHEMBL5612938 — — 1 5.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5613291 — EC50 = 5.0 nM 8.30
CHEMBL5612285 — EC50 = 15.0 nM 7.82
CHEMBL5613620 — EC50 = 16.0 nM 7.80
CHEMBL5612641 — EC50 = 19.0 nM 7.72
CHEMBL5612724 — EC50 = 79.0 nM 7.10
CHEMBL5612163 — EC50 = 123.0 nM 6.91
CHEMBL5612025 — EC50 = 130.0 nM 6.89
CHEMBL5613408 — EC50 = 130.0 nM 6.89
CHEMBL5611999 — EC50 = 155.0 nM 6.81
CHEMBL5612240 — EC50 = 164.0 nM 6.79
CHEMBL5612287 — EC50 = 170.0 nM 6.77
CHEMBL5612686 — EC50 = 181.0 nM 6.74
CHEMBL5612132 — EC50 = 257.0 nM 6.59
CHEMBL5613193 — EC50 = 260.0 nM 6.58
CHEMBL5612722 — EC50 = 288.0 nM 6.54
CHEMBL5613537 — EC50 = 310.0 nM 6.51
CHEMBL5612135 — EC50 = 453.0 nM 6.34
CHEMBL5614323 — EC50 = 463.0 nM 6.33
CHEMBL5613878 — EC50 = 490.0 nM 6.31
CHEMBL5614134 — EC50 = 545.0 nM 6.26
CHEMBL5612162 — EC50 = 580.0 nM 6.24
CHEMBL5614092 — EC50 = 635.0 nM 6.20
CHEMBL581128 — EC50 = 680.0 nM 6.17
CHEMBL5613594 — EC50 = 740.0 nM 6.13
CHEMBL5613052 — EC50 = 860.0 nM 6.07
CHEMBL5613130 — EC50 = 843.0 nM 6.07
CHEMBL5614146 — EC50 = 856.0 nM 6.07
CHEMBL5612661 — EC50 = 1000.0 nM 6.00
CHEMBL5611976 — EC50 = 1050.0 nM 5.98
CHEMBL5612938 — EC50 = 1040.0 nM 5.98
CHEMBL5613049 — EC50 = 1130.0 nM 5.95
CHEMBL5612916 — EC50 = 1120.0 nM 5.95
CHEMBL5613454 — EC50 = 2070.0 nM 5.68
CHEMBL5613593 — EC50 = 2180.0 nM 5.66
CHEMBL5613389 — EC50 = 2300.0 nM 5.64
CHEMBL5613855 — EC50 = 2360.0 nM 5.63
CHEMBL5611990 — EC50 = 2330.0 nM 5.63
CHEMBL5614337 — EC50 = 2480.0 nM 5.61
CHEMBL5613641 — EC50 = 2500.0 nM 5.60
CHEMBL5612653 — EC50 = 3850.0 nM 5.42
CHEMBL5613314 — EC50 = 5630.0 nM 5.25
CHEMBL5612761 — EC50 > 10000.0 nM -
CHEMBL5612479 — EC50 > 10000.0 nM -
CHEMBL5612608 — EC50 > 10000.0 nM -