Assay Detail
Functional
CHEMBL5609742
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Antiplasmodial activity against drug-resistant recrudescent Plasmodium falciparum Dd2-B2 in 2x10^7 bulk culture selection assessed as inhibition of parasite growth incubated for 72 hrs by flow cytometry
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.43 | 7.43 |
| EC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5613620 | — | — | 2 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5613620 | — | EC50 | = | 37.5 | nM | 7.43 |
| CHEMBL5613620 | — | EC90 | = | 68.9 | nM | - |