Assay Detail
Functional
CHEMBL5609745
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Antiplasmodial activity against ring stage of Plasmodium falciparum 3D7 expressing ABCI3-HAreg assessed as inhibition of parasite proliferation incubated for 72 hrs in presence of ABCI3 inhibitor, GlcN by SYBR dye based flow cytometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.30 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5613620 | — | — | 1 | 9.10 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.95 |
| CHEMBL5612025 | — | — | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5613620 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL76 | CHLOROQUINE | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL5612025 | — | EC50 | = | 13.9 | nM | 7.86 |