Assay Detail
Functional
CHEMBL5609751
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Antiplasmodial activity against multidrug-resistant Plasmodium falciparum Dd2 harboring PI4K-S743F mutant infected in erythrocytes assessed as inhibition of parasite growth incubated for 72 hrs by [3H]hypoxanthine incorporation based microbeta counting analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.42 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5613620 | — | — | 1 | 8.22 |
| CHEMBL2041980 | MMV-048 | 2.0 | 1 | 7.05 |
| CHEMBL5612025 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5613620 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2041980 | MMV-048 | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5612025 | — | EC50 | = | 101.0 | nM | 7.00 |