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Assay Detail

CHEMBL5609885

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antivirulence activity against Pseudomonas aeruginosa PA14 assessed as inhibition of pyocyanin biosynthesis incubated for 16 hrs under agitation by photometric analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Pseudomonas aeruginosa
Confidence 1 — Organism
Curated By Autocuration

Target

Pseudomonas aeruginosa (CHEMBL348)
Type ORGANISM
Organism Pseudomonas aeruginosa

Publication

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity.
Abdelsamie AS, Hamed MM, Schütz C, Röhrig T, Kany AM, Schmelz S, Blankenfeldt W, Hirsch AKH, Hartmann RW, Empting M.
Eur J Med Chem (2024) 276 : 116685 -116685
PubMed 39042991 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 6.51 7.06

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5613913 1 7.06
CHEMBL5613188 1 7.06
CHEMBL5613568 1 7.01
CHEMBL5614294 1 6.97
CHEMBL5613313 1 6.96
CHEMBL5613132 1 6.94
CHEMBL5612433 1 6.93
CHEMBL5612613 1 6.75
CHEMBL5090908 1 6.70
CHEMBL5613660 1 6.67
CHEMBL5612560 1 6.65
CHEMBL5612748 1 6.56
CHEMBL5613844 1 6.54
CHEMBL5612699 1 6.52
CHEMBL5613375 1 6.47
CHEMBL5613734 1 6.39
CHEMBL5614029 1 6.37
CHEMBL5614261 1 6.35
CHEMBL5613187 1 6.30
CHEMBL5613840 1 6.29
CHEMBL5611969 1 6.28
CHEMBL5612884 1 6.24
CHEMBL5612171 1 6.23
CHEMBL5612829 1 6.16
CHEMBL5613166 1 6.14
CHEMBL5614116 1 6.12
CHEMBL5613030 1 5.86
CHEMBL5614357 1 5.63
CHEMBL5612801 1 -
CHEMBL5611945 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5613913 IC50 = 88.0 nM 7.06
CHEMBL5613188 IC50 = 87.0 nM 7.06
CHEMBL5613568 IC50 = 98.0 nM 7.01
CHEMBL5614294 IC50 = 106.0 nM 6.97
CHEMBL5613313 IC50 = 109.0 nM 6.96
CHEMBL5613132 IC50 = 114.0 nM 6.94
CHEMBL5612433 IC50 = 118.0 nM 6.93
CHEMBL5612613 IC50 = 179.0 nM 6.75
CHEMBL5090908 IC50 = 200.0 nM 6.70
CHEMBL5613660 IC50 = 215.0 nM 6.67
CHEMBL5612560 IC50 = 226.0 nM 6.65
CHEMBL5612748 IC50 = 274.0 nM 6.56
CHEMBL5613844 IC50 = 290.0 nM 6.54
CHEMBL5612699 IC50 = 302.0 nM 6.52
CHEMBL5613375 IC50 = 338.0 nM 6.47
CHEMBL5613734 IC50 = 406.0 nM 6.39
CHEMBL5614029 IC50 = 424.0 nM 6.37
CHEMBL5614261 IC50 = 450.0 nM 6.35
CHEMBL5613187 IC50 = 500.0 nM 6.30
CHEMBL5613840 IC50 = 515.0 nM 6.29
CHEMBL5611969 IC50 = 524.0 nM 6.28
CHEMBL5612884 IC50 = 576.0 nM 6.24
CHEMBL5612171 IC50 = 591.0 nM 6.23
CHEMBL5612829 IC50 = 696.0 nM 6.16
CHEMBL5613166 IC50 = 718.0 nM 6.14
CHEMBL5614116 IC50 = 761.0 nM 6.12
CHEMBL5613030 IC50 = 1395.0 nM 5.86
CHEMBL5614357 IC50 = 2367.0 nM 5.63
CHEMBL5613018 IC50 > 5.0 nM -
CHEMBL5612286 IC50 > 5.0 nM -
CHEMBL5612643 IC50 > 5.0 nM -
CHEMBL5614141 IC50 > 5.0 nM -
CHEMBL5612551 IC50 > 5.0 nM -
CHEMBL5613571 IC50 > 5.0 nM -
CHEMBL5612090 IC50 > 5.0 nM -
CHEMBL5611945 IC50 > 5.0 nM -
CHEMBL5612801 IC50 > 5.0 nM -