Assay Detail
Functional
CHEMBL5610313
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Antiproliferative activity against human MV4-11 cells assessed as cell viability by measuring amount of ATP after 72 hrs incubation by CellTiteer-Glo Cell viability assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.76 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5612869 | — | — | 1 | 6.30 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 6.15 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5612869 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2364628 | RICOLINOSTAT | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL99 | TRICHOSTATIN | EC50 | = | 15300.0 | nM | 4.82 |