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Assay Detail

CHEMBL5610317

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FABP1 incubated for 3 mins by fluorescence based analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty acid-binding protein, liver (CHEMBL5421)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors.
Chen L, Wang B, Li H, Mao J, Liang Z, Chen Y, Yu M, Liu Y, Liao Z, Yang Y, Wu X, Wang H, Yang Y, Xiang R, Zhang L, Li Z.
Eur J Med Chem (2024) 276 : 116705 -116705
PubMed 39067439 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.56 5.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5612524 1 5.93
CHEMBL5612235 1 5.74
CHEMBL5613265 1 5.68
CHEMBL5612678 1 5.61
CHEMBL5614355 1 5.58
CHEMBL247920 1 5.57
CHEMBL5613315 1 5.52
CHEMBL5613794 1 5.49
CHEMBL5612128 1 5.25
CHEMBL5611914 1 5.21
CHEMBL1413304 1 -
CHEMBL5612331 1 -
CHEMBL5613462 1 -
CHEMBL5612376 1 -
CHEMBL5612308 1 -
CHEMBL5613380 1 -
CHEMBL5614035 1 -
CHEMBL5612229 1 -
CHEMBL1608185 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5612524 IC50 = 1180.0 nM 5.93
CHEMBL5612235 IC50 = 1820.0 nM 5.74
CHEMBL5613265 IC50 = 2110.0 nM 5.68
CHEMBL5612678 IC50 = 2440.0 nM 5.61
CHEMBL5614355 IC50 = 2660.0 nM 5.58
CHEMBL247920 IC50 = 2710.0 nM 5.57
CHEMBL5613315 IC50 = 3020.0 nM 5.52
CHEMBL5613794 IC50 = 3240.0 nM 5.49
CHEMBL5612128 IC50 = 5660.0 nM 5.25
CHEMBL5611914 IC50 = 6110.0 nM 5.21
CHEMBL1413304 IC50 - -
CHEMBL5612331 IC50 - -
CHEMBL5613462 IC50 - -
CHEMBL5612376 IC50 - -
CHEMBL5612308 IC50 - -
CHEMBL5613380 IC50 - -
CHEMBL5614035 IC50 - -
CHEMBL5612229 IC50 - -
CHEMBL1608185 IC50 - -