Assay Detail

CHEMBL5610337

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Functional

Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 96 hrs by SRB assay

ChEMBL ↗

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Target

HT-29 (CHEMBL384) ↗

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HT-29 (CHEMBL384) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HT-29

CHEMBL384

Anchored from Assay target.

Protein identity HT-29

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HT-29
Confidence	1 — Organism
Curated By	Autocuration

Target

HT-29 (CHEMBL384) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads.

Xi M, Zhu J, Zhang F, Shen H, Chen J, Xiao Z, Huangfu Y, Wu C, Sun H, Xia G.
Eur J Med Chem (2024) 276 : 116709 -116709
PubMed 39068862 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.74	10.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39541	DOLASTATIN-10	2.0	1	10.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39541	DOLASTATIN-10	IC50	=	0.018	nM	10.74