Assay Detail
Binding
CHEMBL5610443
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Inhibition of MERS-CoV 3CLpro using Dabcyl-KTSAVLQSGFRKM-Glu(Edans) as substrate preincubated 1 hr in presence of 2 mM GSH followed by substrate addition and measured after 30 mins by FRET assay
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.77 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2365410 | — | — | 2 | 6.47 |
| CHEMBL5614072 | — | — | 2 | 6.01 |
| CHEMBL5612841 | — | — | 2 | 5.89 |
| CHEMBL586628 | — | — | 2 | 5.60 |
| CHEMBL5611903 | — | — | 2 | 5.56 |
| CHEMBL5612402 | — | — | 2 | 5.54 |
| CHEMBL5612298 | — | — | 2 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2365410 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2365410 | — | IC50 | = | 338.84 | nM | 6.47 |
| CHEMBL5614072 | — | IC50 | = | 977.24 | nM | 6.01 |
| CHEMBL5614072 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5612841 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5612841 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL586628 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL586628 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL5611903 | — | IC50 | = | 2754.23 | nM | 5.56 |
| CHEMBL5611903 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5612402 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5612402 | — | IC50 | = | 2951.21 | nM | 5.53 |
| CHEMBL5612298 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5612298 | — | IC50 | = | 5011.87 | nM | 5.30 |