Assay Detail
Binding
CHEMBL5611200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST tagged full length human recombinant HDAC6 (1 to 1215 residues) extracted from Sf9 cells using Z-Lys(Ac)-AMC as substrate measured after 90 mins by fluorescence based microplate reader analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with <i>In Vitro</i> and <i>In Vivo</i> Activity in Neurodegenerative Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.34 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5612392 | — | — | 1 | 7.92 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.54 |
| CHEMBL5612289 | — | — | 1 | 7.46 |
| CHEMBL5611957 | — | — | 1 | 6.78 |
| CHEMBL5612800 | — | — | 1 | 6.53 |
| CHEMBL5613926 | — | — | 1 | - |
| CHEMBL4173258 | — | — | 1 | - |
| CHEMBL5614106 | — | — | 1 | - |
| CHEMBL5612700 | — | — | 1 | - |
| CHEMBL5614345 | — | — | 1 | - |
| CHEMBL5613087 | — | — | 1 | - |
| CHEMBL5613964 | — | — | 1 | - |
| CHEMBL5612956 | — | — | 1 | - |
| CHEMBL5613368 | — | — | 1 | - |
| CHEMBL5614364 | — | — | 1 | - |
| CHEMBL5613800 | — | — | 1 | - |
| CHEMBL5613037 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5612392 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5612289 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5611957 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL5612800 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL5613926 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4173258 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5614106 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612700 | — | IC50 | > | 3333.0 | nM | - |
| CHEMBL5614345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613087 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5612956 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5614364 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5613037 | — | IC50 | > | 10000.0 | nM | - |