Assay Detail
Binding
CHEMBL5611214
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5-HT6 receptor extracted from CHO-K1 cell membrane assessed as inhibition constant incubated for 1 hr by Microbeta plate reader analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Contilisant+Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with <i>In Vitro</i> and <i>In Vivo</i> Activity in Neurodegenerative Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.16 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5612392 | — | — | 1 | 5.47 |
| CHEMBL5612956 | — | — | 1 | 5.37 |
| CHEMBL5614364 | — | — | 1 | 5.24 |
| CHEMBL5612289 | — | — | 1 | 5.20 |
| CHEMBL5613964 | — | — | 1 | 4.51 |
| CHEMBL268229 | — | — | 1 | - |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5612392 | — | Ki | = | 3392.0 | nM | 5.47 |
| CHEMBL5612956 | — | Ki | = | 4307.0 | nM | 5.37 |
| CHEMBL5614364 | — | Ki | = | 5820.0 | nM | 5.24 |
| CHEMBL5612289 | — | Ki | = | 6376.0 | nM | 5.20 |
| CHEMBL5613964 | — | Ki | = | 30650.0 | nM | 4.51 |
| CHEMBL268229 | — | Ki | - | — | - | |
| CHEMBL95 | TACRINE | Ki | - | — | - | |
| CHEMBL396778 | SAFINAMIDE | Ki | - | — | - | |
| CHEMBL887 | RASAGILINE | Ki | - | — | - |