Assay Detail
Binding
CHEMBL5611693
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Inhibition of Bfl-1 in human SU-DHL-1 cells assessed as caspase-3/7 activation measured after 6 hrs by UPLC-MRM MS analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SU-DHL-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.53 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5613766 | — | — | 1 | 6.43 |
| CHEMBL5613621 | — | — | 1 | 5.80 |
| CHEMBL5613029 | — | — | 1 | 5.75 |
| CHEMBL5614064 | — | — | 1 | 5.58 |
| CHEMBL5612634 | — | — | 1 | 5.43 |
| CHEMBL5613885 | — | — | 1 | 5.16 |
| CHEMBL5612066 | — | — | 1 | 5.13 |
| CHEMBL5613717 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5613766 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5613621 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5613029 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5614064 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5612634 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5613885 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5612066 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL5613717 | — | EC50 | = | 11000.0 | nM | 4.96 |