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Assay Detail

CHEMBL5614480

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Functional
Antiproliferative activity against human A549 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Hydroxamic acid hybrids: Histone deacetylase inhibitors with anticancer therapeutic potency.
Pan Y, Hou H, Zhou B, Gao J, Gao F.
Eur J Med Chem (2023) 262 : 115879 -115879
PubMed 37875056 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.35 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4639966 1 7.30
CHEMBL5618128 1 6.85
CHEMBL5427062 1 6.75
CHEMBL5435505 1 6.64
CHEMBL5618320 1 6.44
CHEMBL5620123 1 6.43
CHEMBL1287853 FEDRATINIB 4.0 1 6.25
CHEMBL98 VORINOSTAT 4.0 1 6.21
CHEMBL5618579 1 6.14
CHEMBL5619541 1 5.85
CHEMBL5618705 1 5.66
CHEMBL5619313 1 5.66
CHEMBL269538 HARMINE 1.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4639966 IC50 = 50.0 nM 7.30
CHEMBL5618128 IC50 = 140.0 nM 6.85
CHEMBL5427062 IC50 = 180.0 nM 6.75
CHEMBL5435505 IC50 = 230.0 nM 6.64
CHEMBL5618320 IC50 = 360.0 nM 6.44
CHEMBL5620123 IC50 = 370.0 nM 6.43
CHEMBL1287853 FEDRATINIB IC50 = 560.0 nM 6.25
CHEMBL98 VORINOSTAT IC50 = 610.0 nM 6.21
CHEMBL5618579 IC50 = 730.0 nM 6.14
CHEMBL5619541 IC50 = 1410.0 nM 5.85
CHEMBL5618705 IC50 = 2200.0 nM 5.66
CHEMBL5619313 IC50 = 2200.0 nM 5.66
CHEMBL269538 HARMINE IC50 > 20000.0 nM -