Assay Detail
Functional
CHEMBL5614482
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Antiproliferative activity against human MDA-MB-231 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxamic acid hybrids: Histone deacetylase inhibitors with anticancer therapeutic potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.37 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639966 | — | — | 1 | 7.30 |
| CHEMBL5618128 | — | — | 1 | 6.85 |
| CHEMBL5619770 | — | — | 1 | 6.71 |
| CHEMBL5618320 | — | — | 1 | 6.44 |
| CHEMBL5620123 | — | — | 1 | 6.43 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 6.25 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.21 |
| CHEMBL5618579 | — | — | 1 | 6.14 |
| CHEMBL5618705 | — | — | 1 | 5.66 |
| CHEMBL5619313 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639966 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5618128 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5619770 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL5618320 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5620123 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1287853 | FEDRATINIB | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5618579 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5618705 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5619313 | — | IC50 | = | 2200.0 | nM | 5.66 |