Assay Detail
Binding
CHEMBL5614718
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Inhibition of HDAC1 (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence based microplate reader analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hydroxamic acid hybrids: Histone deacetylase inhibitors with anticancer therapeutic potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.88 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5619922 | — | — | 1 | 8.10 |
| CHEMBL5618296 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5619922 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5618296 | — | IC50 | = | 22.0 | nM | 7.66 |