Assay Detail

CHEMBL5614737

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Functional

Antiproliferative activity against human NCI-H157 cells

ChEMBL ↗

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Target

NCI-H157 (CHEMBL614783) ↗

Open DB target context

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NCI-H157 (CHEMBL614783) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NCI-H157

CHEMBL614783

Anchored from Assay target.

Protein identity NCI-H157

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H157
Confidence	1 — Organism
Curated By	Autocuration

Target

NCI-H157 (CHEMBL614783) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Hydroxamic acid hybrids: Histone deacetylase inhibitors with anticancer therapeutic potency.

Pan Y, Hou H, Zhou B, Gao J, Gao F.
Eur J Med Chem (2023) 262 : 115879 -115879
PubMed 37875056 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.15	6.44

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5618320	—	—	1	6.44
CHEMBL5618579	—	—	1	6.14
CHEMBL98	VORINOSTAT	4.0	1	5.88

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5618320	—	IC50	=	360.0	nM	6.44
CHEMBL5618579	—	IC50	=	730.0	nM	6.14
CHEMBL98	VORINOSTAT	IC50	=	1330.0	nM	5.88