Assay Detail
Binding
CHEMBL5615232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated Fc-tagged ephrin-A1 from C/N-terminal 6-His tagged mouse recombinant EphA2 (Ala22 to Ala535 residues) preincubated for 1 hr followed by ephrin-A1-Fc addition and measured after 4 to 5 hrs by ELISA assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.00 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5619189 | — | — | 1 | 5.58 |
| CHEMBL5618209 | — | — | 1 | 5.44 |
| CHEMBL5619481 | — | — | 1 | 5.33 |
| CHEMBL3735992 | — | — | 1 | 5.27 |
| CHEMBL5618680 | — | — | 1 | 5.26 |
| CHEMBL5620271 | — | — | 1 | 5.25 |
| CHEMBL5619502 | — | — | 1 | 5.16 |
| CHEMBL5619796 | — | — | 1 | 5.09 |
| CHEMBL5620315 | — | — | 1 | 5.09 |
| CHEMBL5618992 | — | — | 1 | 5.08 |
| CHEMBL5619612 | — | — | 1 | 5.00 |
| CHEMBL5620294 | — | — | 1 | 4.92 |
| CHEMBL5620153 | — | — | 1 | 4.80 |
| CHEMBL5618293 | — | — | 1 | 4.80 |
| CHEMBL5618286 | — | — | 1 | 4.70 |
| CHEMBL5620004 | — | — | 1 | 4.62 |
| CHEMBL5619360 | — | — | 1 | 4.62 |
| CHEMBL5620093 | — | — | 1 | 4.54 |
| CHEMBL5618542 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5619189 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5618209 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5619481 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3735992 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5618680 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5620271 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5619502 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5619796 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5620315 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5618992 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5619612 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5620294 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5620153 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5618293 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5618286 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5620004 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5619360 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5620093 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5618542 | — | IC50 | = | 38000.0 | nM | 4.42 |