Assay Detail
Binding
CHEMBL5615844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 NL4-3 monomeric capsid protein
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Structural capsid protein (CHEMBL2366504) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A comprehensive review of new small molecule drugs approved by the FDA in 2022: Advance and prospect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.84 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4594438 | LENACAPAVIR | 4.0 | 1 | 10.30 |
| CHEMBL5619085 | — | — | 1 | 9.70 |
| CHEMBL5618694 | — | — | 1 | 7.92 |
| CHEMBL5618074 | — | — | 1 | 7.72 |
| CHEMBL5619180 | — | — | 1 | 7.28 |
| CHEMBL5618551 | — | — | 1 | 6.82 |
| CHEMBL5618387 | — | — | 1 | 6.78 |
| CHEMBL5619879 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4594438 | LENACAPAVIR | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL5619085 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5618694 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5618074 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5619180 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5618551 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5618387 | — | EC50 | = | 167.0 | nM | 6.78 |
| CHEMBL5619879 | — | EC50 | = | 650.0 | nM | 6.19 |