Assay Detail
Functional
CHEMBL5615935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of paclitaxel resistance in human MCF7ADR cells assessed as reduction in paclitaxel IC50 at 10 uM pretreated with compound for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 6.68 +/- 0.35 microM)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.58 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5619934 | — | — | 1 | 8.00 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5619934 | — | IC50 | = | 10.07 | nM | 8.00 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 69.51 | nM | 7.16 |