Assay Detail
Binding
CHEMBL5616324
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Inhibition of PTP1B/PTPN2 (unknown origin) in mouse B16 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | B16 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Regulation of protein phosphorylation by PTPN2 and its small-molecule inhibitors/degraders as a potential disease treatment strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.17 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095164 | OSUNPROTAFIB | 2.0 | 1 | 6.75 |
| CHEMBL5619195 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095164 | OSUNPROTAFIB | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5619195 | — | EC50 | = | 2651.0 | nM | 5.58 |