Assay Detail
Functional
CHEMBL5616325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse B16 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Regulation of protein phosphorylation by PTPN2 and its small-molecule inhibitors/degraders as a potential disease treatment strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.18 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5095164 | OSUNPROTAFIB | 2.0 | 1 | 7.19 |
| CHEMBL5618445 | — | — | 1 | 6.89 |
| CHEMBL5618850 | — | — | 1 | 6.80 |
| CHEMBL5618838 | — | — | 1 | 6.16 |
| CHEMBL5619752 | — | — | 1 | 6.11 |
| CHEMBL5618163 | — | — | 1 | 5.85 |
| CHEMBL5618189 | — | — | 1 | 5.30 |
| CHEMBL5619999 | — | — | 1 | 5.11 |
| CHEMBL5619034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5095164 | OSUNPROTAFIB | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5618445 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5618850 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5618838 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5619752 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5618163 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5618189 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5619999 | — | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL5619034 | — | IC50 | < | 5000.0 | nM | - |