Assay Detail
Functional
CHEMBL5616465
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Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.18 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498221 | — | — | 1 | 8.85 |
| CHEMBL5620130 | — | — | 1 | 8.33 |
| CHEMBL5620115 | — | — | 1 | 8.02 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.00 |
| CHEMBL5619785 | — | — | 1 | 7.70 |
| CHEMBL5620215 | — | — | 1 | - |
| CHEMBL5618416 | — | — | 1 | - |
| CHEMBL5619475 | — | — | 1 | - |
| CHEMBL5618675 | — | — | 1 | - |
| CHEMBL5619463 | — | — | 1 | - |
| CHEMBL5618352 | — | — | 1 | - |
| CHEMBL5618485 | — | — | 1 | - |
| CHEMBL5618087 | — | — | 1 | - |
| CHEMBL5618561 | — | — | 1 | - |
| CHEMBL5619417 | — | — | 1 | - |
| CHEMBL5618930 | — | — | 1 | - |
| CHEMBL5618848 | — | — | 1 | - |
| CHEMBL5619197 | — | — | 1 | - |
| CHEMBL5618311 | — | — | 1 | - |
| CHEMBL5619762 | — | — | 1 | - |
| CHEMBL5618776 | — | — | 1 | - |
| CHEMBL5618763 | — | — | 1 | - |
| CHEMBL5620298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498221 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5620130 | — | IC50 | = | 4.68 | nM | 8.33 |
| CHEMBL5620115 | — | IC50 | = | 9.53 | nM | 8.02 |
| CHEMBL107 | COLCHICINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5619785 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5620215 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618416 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5619475 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618675 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5619463 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618352 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618485 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618087 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618561 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5619417 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618930 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618848 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5619197 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618311 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5619762 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618776 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5618763 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL5620298 | — | IC50 | > | 100.0 | nM | - |