Assay Detail
Functional
CHEMBL5617875
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.75 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5618343 | — | — | 1 | 8.46 |
| CHEMBL5619476 | — | — | 1 | 7.78 |
| CHEMBL4650521 | BATOPROTAFIB | 2.0 | 1 | 7.41 |
| CHEMBL5618733 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5618343 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5619476 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL4650521 | BATOPROTAFIB | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5618733 | — | IC50 | = | 45.5 | nM | 7.34 |