Assay Detail

CHEMBL5620482

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Binding

Inhibition of LCK (unknown origin)

ChEMBL ↗

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Target

Tyrosine-protein kinase Lck (CHEMBL258) ↗

Open DB target context

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Tyrosine-protein kinase Lck (CHEMBL258) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase Lck

CHEMBL258

Anchored from Assay target.

Protein identity Tyrosine-protein kinase Lck

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase Lck (CHEMBL258) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.

Wen J, Wang S, Guo R, Liu D.
Eur J Med Chem (2023) 245 : 114884 -114884
PubMed 36335744 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.82	7.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1614710	OSI-930	1.0	1	7.82

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1614710	OSI-930	IC50	=	15.0	nM	7.82