Assay Detail
Binding
CHEMBL5620535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PDE7A1 (130 to 482 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (CHEMBL3012) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in the development of phosphodiesterase 7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.34 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630424 | — | — | 1 | 6.85 |
| CHEMBL484928 | — | — | 1 | 6.58 |
| CHEMBL1911416 | — | — | 1 | 6.09 |
| CHEMBL4756052 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630424 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL484928 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1911416 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4756052 | — | IC50 | = | 1400.0 | nM | 5.85 |