Assay Detail
Binding
CHEMBL5620536
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE7B (unknown origin) by 3H-cAMP scintillation proximity assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 7B (CHEMBL4716) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in the development of phosphodiesterase 7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.51 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630984 | — | — | 1 | 7.85 |
| CHEMBL5625140 | — | — | 1 | 7.64 |
| CHEMBL484928 | — | — | 1 | 6.21 |
| CHEMBL503012 | — | — | 1 | 5.77 |
| CHEMBL451589 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630984 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5625140 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL484928 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL503012 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL451589 | — | IC50 | = | 8800.0 | nM | 5.06 |