Assay Detail
Binding
CHEMBL5620562
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Inhibition of human recombinant MAO-B
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 5-(2-hydroxyphenyl)-2-phthalide-3(3H)-pyrazolones as balanced multifunctional agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.59 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 8.15 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.77 |
| CHEMBL5630122 | — | — | 1 | 6.66 |
| CHEMBL5624766 | — | — | 1 | 6.39 |
| CHEMBL5630375 | — | — | 1 | 6.25 |
| CHEMBL5630148 | — | — | 1 | 6.05 |
| CHEMBL5625129 | — | — | 1 | 5.54 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.50 |
| CHEMBL5630301 | — | — | 1 | 5.46 |
| CHEMBL5630870 | — | — | 1 | 5.42 |
| CHEMBL5625120 | — | — | 1 | 5.41 |
| CHEMBL5625134 | — | — | 1 | 5.36 |
| CHEMBL5629989 | — | — | 1 | 5.29 |
| CHEMBL5624890 | — | — | 1 | 5.26 |
| CHEMBL5624840 | — | — | 1 | 5.21 |
| CHEMBL5625098 | — | — | 1 | 5.20 |
| CHEMBL5629975 | — | — | 1 | 5.19 |
| CHEMBL5624459 | — | — | 1 | 5.13 |
| CHEMBL5631053 | — | — | 1 | 5.12 |
| CHEMBL5624656 | — | — | 1 | 5.09 |
| CHEMBL5630370 | — | — | 1 | 5.08 |
| CHEMBL5630198 | — | — | 1 | 5.03 |
| CHEMBL5631106 | — | — | 1 | 5.03 |
| CHEMBL5624777 | — | — | 1 | 4.98 |
| CHEMBL5624646 | — | — | 1 | 4.94 |
| CHEMBL5629924 | — | — | 1 | 4.91 |
| CHEMBL5630013 | — | — | 1 | - |
| CHEMBL5630070 | — | — | 1 | - |
| CHEMBL5631168 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL887 | RASAGILINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5630122 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5624766 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5630375 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5630148 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5625129 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL5630301 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL5630870 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL5625120 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL5625134 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL5629989 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL5624890 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL5624840 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5625098 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL5629975 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5624459 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL5631053 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL5624656 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL5630370 | — | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL5630198 | — | IC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL5631106 | — | IC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL5624777 | — | IC50 | = | 10480.0 | nM | 4.98 |
| CHEMBL5624646 | — | IC50 | = | 11430.0 | nM | 4.94 |
| CHEMBL5629924 | — | IC50 | = | 12350.0 | nM | 4.91 |
| CHEMBL5630013 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5630070 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5631168 | — | IC50 | > | 10000.0 | nM | - |