Assay Detail

CHEMBL5620821

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Binding

Inhibition of JAK1 (unknown origin)

ChEMBL ↗

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Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Open DB target context

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Tyrosine-protein kinase JAK1 (CHEMBL2835) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase JAK1

CHEMBL2835

Anchored from Assay target.

Protein identity Tyrosine-protein kinase JAK1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Recent advance of small-molecule drugs for clinical treatment of multiple myeloma.

Zhao JH, Xu QL, Ma S, Li CY, Zhang HC, Zhao LJ, Zhang ZY.
Eur J Med Chem (2023) 257 : 115492 -115492
PubMed 37210838 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.48	8.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1795071	RUXOLITINIB PHOSPHATE	4.0	1	8.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1795071	RUXOLITINIB PHOSPHATE	IC50	=	3.3	nM	8.48