Assay Detail

CHEMBL5620835

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Binding

Inhibition of NF-kappaB (unknown origin)

ChEMBL ↗

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Target

Nuclear factor NF-kappa-B complex (CHEMBL2094258) ↗

Open DB target context

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Nuclear factor NF-kappa-B complex (CHEMBL2094258) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Nuclear factor NF-kappa-B complex

CHEMBL2094258

Anchored from Assay target.

Protein identity Nuclear factor NF-kappa-B complex

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Nuclear factor NF-kappa-B complex (CHEMBL2094258) ↗

Type	PROTEIN COMPLEX GROUP
Organism	Homo sapiens

Publication

Recent advance of small-molecule drugs for clinical treatment of multiple myeloma.

Zhao JH, Xu QL, Ma S, Li CY, Zhang HC, Zhao LJ, Zhang ZY.
Eur J Med Chem (2023) 257 : 115492 -115492
PubMed 37210838 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.30	9.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL384467	DEXAMETHASONE	4.0	1	9.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL384467	DEXAMETHASONE	IC50	=	0.5	nM	9.30