Assay Detail
Functional
CHEMBL5621722
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Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.76 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.70 |
| CHEMBL5173063 | — | — | 1 | 8.05 |
| CHEMBL5630023 | — | — | 1 | 8.05 |
| CHEMBL5630133 | — | — | 1 | 7.82 |
| CHEMBL5624856 | — | — | 1 | 7.77 |
| CHEMBL5630989 | — | — | 1 | 7.42 |
| CHEMBL5629862 | — | — | 1 | 7.16 |
| CHEMBL5625141 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5173063 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5630023 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5630133 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5624856 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5630989 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5629862 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5625141 | — | IC50 | = | 80.0 | nM | 7.10 |