Assay Detail
Binding
CHEMBL5621854
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Inhibition of VEGFR-2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Research progress of VEGFR small molecule inhibitors in ocular neovascular diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.61 | 10.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 10.46 |
| CHEMBL105739 | — | — | 1 | 7.40 |
| CHEMBL404466 | — | — | 1 | 6.42 |
| CHEMBL261508 | — | — | 1 | 6.16 |
| CHEMBL4303201 | CATEQUENTINIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL105739 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL404466 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL261508 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4303201 | CATEQUENTINIB | IC50 | < | 1.0 | nM | - |