Assay Detail
Binding
CHEMBL5622045
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Binding affinity to human recombinant CD73 assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Advances in CD73 inhibitors for immunotherapy: Antibodies, synthetic small molecule compounds, and natural compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.40 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5624492 | — | — | 1 | 9.50 |
| CHEMBL5630200 | — | — | 1 | 8.66 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | 7.05 |
| CHEMBL5631165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5624492 | — | Ki | = | 0.318 | nM | 9.50 |
| CHEMBL5630200 | — | Ki | = | 2.21 | nM | 8.66 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | Ki | = | 88.4 | nM | 7.05 |
| CHEMBL5631165 | — | Ki | = | 0.005 | nM | - |