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Assay Detail

CHEMBL5622191

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBC incubated for 50 hrs by SYBR green I staining based microplate reader assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Cell Type RBC
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria therapeutics.
Madhav H, Patel TS, Rizvi Z, Reddy GS, Rahman A, Rahman MA, Ahmedi S, Fatima S, Saxena K, Manzoor N, Bhattacharjee S, Dixit BC, Sijwali PS, Hoda N.
Eur J Med Chem (2023) 258 : 115564 -115564
PubMed 37321109 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.78 6.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5630121 1 6.28
CHEMBL5630614 1 6.13
CHEMBL5630817 1 6.13
CHEMBL5625072 1 5.97
CHEMBL5624599 1 5.97
CHEMBL5624786 1 5.96
CHEMBL5630622 1 5.92
CHEMBL5630854 1 5.88
CHEMBL5630350 1 5.85
CHEMBL5624653 1 5.84
CHEMBL5629877 1 5.83
CHEMBL5630826 1 5.81
CHEMBL5624669 1 5.79
CHEMBL5631112 1 5.78
CHEMBL5630904 1 5.48
CHEMBL5629998 1 5.16
CHEMBL5631129 1 4.46
CHEMBL5630464 1 -
CHEMBL5624799 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5630121 IC50 = 530.0 nM 6.28
CHEMBL5630614 IC50 = 740.0 nM 6.13
CHEMBL5630817 IC50 = 740.0 nM 6.13
CHEMBL5625072 IC50 = 1060.0 nM 5.97
CHEMBL5624599 IC50 = 1060.0 nM 5.97
CHEMBL5624786 IC50 = 1090.0 nM 5.96
CHEMBL5630622 IC50 = 1200.0 nM 5.92
CHEMBL5630854 IC50 = 1310.0 nM 5.88
CHEMBL5630350 IC50 = 1410.0 nM 5.85
CHEMBL5624653 IC50 = 1460.0 nM 5.84
CHEMBL5629877 IC50 = 1470.0 nM 5.83
CHEMBL5630826 IC50 = 1540.0 nM 5.81
CHEMBL5624669 IC50 = 1620.0 nM 5.79
CHEMBL5631112 IC50 = 1650.0 nM 5.78
CHEMBL5630904 IC50 = 3330.0 nM 5.48
CHEMBL5629998 IC50 = 6870.0 nM 5.16
CHEMBL5631129 IC50 = 34300.0 nM 4.46
CHEMBL5630464 IC50 > 25000.0 nM -
CHEMBL5624799 IC50 > 25000.0 nM -