Assay Detail
Binding
CHEMBL5622376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.3 expressed in CHO cells under resting state by automated patch clamp electrophysiology analysis
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 3 subunit alpha (CHEMBL5163) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New aryl and acylsulfonamides as state-dependent inhibitors of Na<sub>v</sub>1.3 voltage-gated sodium channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 5.18 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | 3.0 | 1 | 8.40 |
| CHEMBL5630885 | — | — | 1 | 5.16 |
| CHEMBL5624805 | — | — | 1 | 4.77 |
| CHEMBL5630002 | — | — | 1 | 4.75 |
| CHEMBL5630861 | — | — | 1 | 4.62 |
| CHEMBL5630791 | — | — | 1 | 4.58 |
| CHEMBL5624797 | — | — | 1 | 4.57 |
| CHEMBL5630705 | — | — | 1 | 4.57 |
| CHEMBL5629870 | — | — | 1 | - |
| CHEMBL5630235 | — | — | 1 | - |
| CHEMBL2137576 | — | — | 1 | - |
| CHEMBL5630638 | — | — | 1 | - |
| CHEMBL5630810 | — | — | 1 | - |
| CHEMBL5624709 | — | — | 1 | - |
| CHEMBL4943076 | — | — | 1 | - |
| CHEMBL5630255 | — | — | 1 | - |
| CHEMBL5630699 | — | — | 1 | - |
| CHEMBL5630513 | — | — | 1 | - |
| CHEMBL5630319 | — | — | 1 | - |
| CHEMBL5630223 | — | — | 1 | - |
| CHEMBL5624922 | — | — | 1 | - |
| CHEMBL1543696 | — | — | 1 | - |
| CHEMBL5630627 | — | — | 1 | - |
| CHEMBL1426769 | — | — | 1 | - |
| CHEMBL5630398 | — | — | 1 | - |
| CHEMBL5631158 | — | — | 1 | - |
| CHEMBL5630208 | — | — | 1 | - |
| CHEMBL5630560 | — | — | 1 | - |
| CHEMBL5630650 | — | — | 1 | - |
| CHEMBL5629953 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5630885 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5624805 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5630002 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5630861 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5630791 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5624797 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5630705 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5624875 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630235 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5625104 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630548 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5625110 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5624791 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5625112 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5631122 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5624820 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630077 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630754 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630779 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5624961 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL629 | AMITRIPTYLINE | IC50 | - | — | - | |
| CHEMBL5624724 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630825 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5631186 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630768 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630639 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5629882 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5624631 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630223 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5629953 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630650 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630560 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630208 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5631158 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630398 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1426769 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630627 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1543696 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5624922 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630319 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5629870 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2137576 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630638 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630810 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5624709 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4943076 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630255 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630699 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5630513 | — | IC50 | > | 30000.0 | nM | - |