Assay Detail
Binding
CHEMBL5622385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.5 expressed in CHO cells under inactivated state by automated patch clamp electrophysiology analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 5 subunit alpha (CHEMBL1980) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New aryl and acylsulfonamides as state-dependent inhibitors of Na<sub>v</sub>1.3 voltage-gated sodium channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.56 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 5.92 |
| CHEMBL5630885 | — | — | 1 | 5.52 |
| CHEMBL5630319 | — | — | 1 | 5.47 |
| CHEMBL5624797 | — | — | 1 | 5.46 |
| CHEMBL5630705 | — | — | 1 | 5.43 |
| CHEMBL5624805 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5630885 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5630319 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5624797 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5630705 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5624805 | — | IC50 | > | 30000.0 | nM | - |