Assay Detail
Functional
CHEMBL5623310
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Cytotoxicity against human MIA PaCa-2 cells incubated for 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.00 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630687 | — | — | 1 | 5.35 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 5.10 |
| CHEMBL5630067 | — | — | 1 | 4.96 |
| CHEMBL5630741 | — | — | 1 | 4.85 |
| CHEMBL339586 | — | — | 1 | 4.75 |
| CHEMBL5631188 | — | — | 1 | - |
| CHEMBL5630644 | — | — | 1 | - |
| CHEMBL5630012 | — | — | 1 | - |
| CHEMBL5624551 | — | — | 1 | - |
| CHEMBL5624865 | — | — | 1 | - |
| CHEMBL5630536 | — | — | 1 | - |
| CHEMBL5630824 | — | — | 1 | - |
| CHEMBL5630633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630687 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5630067 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5630741 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL339586 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5631188 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5630644 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5630012 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5624551 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5624865 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5630536 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5630824 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5630633 | — | IC50 | > | 25000.0 | nM | - |