Assay Detail
Binding
CHEMBL5623736
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Binding affinity to Mycobacterium tuberculosis DHFR assessed as dissociation constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydrofolate reductase (CHEMBL6065) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Recent advances in Fragment-based strategies against tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 6.98 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5629885 | — | — | 1 | 7.77 |
| CHEMBL5081820 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5629885 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL5081820 | — | Kd | = | 640.0 | nM | 6.19 |