Assay Detail
Toxicity
CHEMBL5623903
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Antiproliferative activity against human L02 cells measured after 24 to 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.39 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5630522 | — | — | 1 | 5.41 |
| CHEMBL5630358 | — | — | 1 | 5.37 |
| CHEMBL5625083 | — | — | 1 | - |
| CHEMBL5630288 | — | — | 1 | - |
| CHEMBL5630586 | — | — | 1 | - |
| CHEMBL5625076 | — | — | 1 | - |
| CHEMBL4514636 | FISOGATINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5630522 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL5630358 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL5625083 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5630288 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5630586 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5625076 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4514636 | FISOGATINIB | IC50 | > | 10000.0 | nM | - |