Assay Detail
Binding
CHEMBL5625331
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Inhibition of IDH2 R172Q mutant (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Challenges for the development of mutant isocitrate dehydrogenases 1 inhibitors to treat glioma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.20 | 4.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5631386 | — | — | 1 | 4.38 |
| CHEMBL4439727 | — | — | 1 | 4.02 |
| CHEMBL5633668 | — | — | 1 | - |
| CHEMBL5632655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5631386 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL4439727 | — | IC50 | = | 96300.0 | nM | 4.02 |
| CHEMBL5633668 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5632655 | — | IC50 | > | 100000.0 | nM | - |