Assay Detail

CHEMBL5625548

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Functional

Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay

ChEMBL ↗

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Target

NCI-H460 (CHEMBL396) ↗

Open DB target context

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NCI-H460 (CHEMBL396) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NCI-H460

CHEMBL396

Anchored from Assay target.

Protein identity NCI-H460

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H460
Confidence	1 — Organism
Curated By	Autocuration

Target

NCI-H460 (CHEMBL396) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Pharmacological activity and mechanism of pyrazines.

Hou W, Dai W, Huang H, Liu SL, Liu J, Huang LJ, Huang XH, Zeng JL, Gan ZW, Zhang ZY, Lan JX.
Eur J Med Chem (2023) 258 : 115544 -115544
PubMed 37300915 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.36	10.36

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL269081	CEPHALOSTATIN 1	—	1	10.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL269081	CEPHALOSTATIN 1	IC50	=	0.044	nM	10.36