Assay Detail
Functional
CHEMBL5625569
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Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.47 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229093 | MITOQUINONE CATION | 2.0 | 1 | 6.42 |
| CHEMBL5631806 | — | — | 1 | 5.37 |
| CHEMBL5632244 | — | — | 1 | 5.07 |
| CHEMBL5633816 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229093 | MITOQUINONE CATION | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL5631806 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL5632244 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5633816 | — | IC50 | = | 10100.0 | nM | 5.00 |