Assay Detail
Binding
CHEMBL5626795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant RIPK1 using MBP as substrate preincubated for 15 mins followed by substrate addition and measured after 120 mins in presence of ATP by ADP-Glo kinase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.93 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195008 | NECROSTATIN | — | 1 | 6.57 |
| CHEMBL5632937 | — | — | 1 | 6.16 |
| CHEMBL4779280 | — | — | 1 | 6.03 |
| CHEMBL5632140 | — | — | 1 | 5.78 |
| CHEMBL5629959 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195008 | NECROSTATIN | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL5632937 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4779280 | — | IC50 | = | 929.0 | nM | 6.03 |
| CHEMBL5632140 | — | IC50 | = | 1665.0 | nM | 5.78 |
| CHEMBL5629959 | — | IC50 | = | 8210.0 | nM | 5.09 |