Assay Detail
Binding
CHEMBL5626975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured every 1 min for 20 mins by spectrophotometric analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.27 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.51 |
| CHEMBL5631356 | — | — | 1 | 7.07 |
| CHEMBL5633239 | — | — | 1 | 6.87 |
| CHEMBL5632891 | — | — | 1 | 6.71 |
| CHEMBL5632465 | — | — | 1 | 6.47 |
| CHEMBL5631365 | — | — | 1 | 6.44 |
| CHEMBL5629932 | — | — | 1 | 6.26 |
| CHEMBL5633087 | — | — | 1 | 6.22 |
| CHEMBL5633141 | — | — | 1 | 6.10 |
| CHEMBL5632160 | — | — | 1 | 5.91 |
| CHEMBL5631752 | — | — | 1 | 5.85 |
| CHEMBL5632181 | — | — | 1 | 5.82 |
| CHEMBL5632076 | — | — | 1 | 5.79 |
| CHEMBL5632219 | — | — | 1 | 5.74 |
| CHEMBL5631427 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5631356 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5633239 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL5632891 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5632465 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5631365 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5629932 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5633087 | — | IC50 | = | 607.0 | nM | 6.22 |
| CHEMBL5633141 | — | IC50 | = | 799.0 | nM | 6.10 |
| CHEMBL5632160 | — | IC50 | = | 1219.0 | nM | 5.91 |
| CHEMBL5631752 | — | IC50 | = | 1415.0 | nM | 5.85 |
| CHEMBL5632181 | — | IC50 | = | 1518.0 | nM | 5.82 |
| CHEMBL5632076 | — | IC50 | = | 1608.0 | nM | 5.79 |
| CHEMBL5632219 | — | IC50 | = | 1824.0 | nM | 5.74 |
| CHEMBL5631427 | — | IC50 | = | 4637.0 | nM | 5.33 |