Assay Detail
Binding
CHEMBL5626981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GluN1-1a/GluN2B (unknown origin) expressed in xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced channel current incubated for 20s measured at holding potential of -70 mV by two-electrode voltage clamp technique
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.78 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 6.11 |
| CHEMBL5631356 | — | — | 1 | 5.41 |
| CHEMBL5633239 | — | — | 1 | 5.30 |
| CHEMBL5632076 | — | — | 1 | 4.66 |
| CHEMBL5629932 | — | — | 1 | 4.42 |
| CHEMBL5632160 | — | — | 1 | 4.20 |
| CHEMBL5633141 | — | — | 1 | 4.10 |
| CHEMBL5632219 | — | — | 1 | 4.01 |
| CHEMBL5632181 | — | — | 1 | - |
| CHEMBL5631427 | — | — | 1 | - |
| CHEMBL5632465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL5631356 | — | IC50 | = | 3876.0 | nM | 5.41 |
| CHEMBL5633239 | — | IC50 | = | 5054.0 | nM | 5.30 |
| CHEMBL5632076 | — | IC50 | = | 21771.0 | nM | 4.66 |
| CHEMBL5629932 | — | IC50 | = | 38177.0 | nM | 4.42 |
| CHEMBL5632160 | — | IC50 | = | 63650.0 | nM | 4.20 |
| CHEMBL5633141 | — | IC50 | = | 79450.0 | nM | 4.10 |
| CHEMBL5632219 | — | IC50 | = | 97293.0 | nM | 4.01 |
| CHEMBL5632181 | — | IC50 | = | 216556.0 | nM | - |
| CHEMBL5631427 | — | IC50 | = | 115634.0 | nM | - |
| CHEMBL5632465 | — | IC50 | = | 196940.0 | nM | - |