Assay Detail
Binding
CHEMBL5626985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GluN1-1a/GluN2C (unknown origin) expressed in xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced channel current incubated for 20s measured at holding potential of -70 mV by two-electrode voltage clamp technique
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.35 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 6.65 |
| CHEMBL5631356 | — | — | 1 | 4.04 |
| CHEMBL5633239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL807 | MEMANTINE | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL5631356 | — | IC50 | = | 90190.0 | nM | 4.04 |
| CHEMBL5633239 | — | IC50 | = | 143000.0 | nM | - |