Assay Detail
Binding
CHEMBL5627508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6xHis-tagged human recombinant RIPK2 incubated for 1 hr by nanoBRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 2 (CHEMBL5014) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
RIPK2 inhibitors for disease therapy: Current status and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.60 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4781373 | — | — | 1 | 7.70 |
| CHEMBL4786742 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4781373 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL4786742 | — | IC50 | = | 32.0 | nM | 7.50 |