Assay Detail
Functional
CHEMBL5627780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3, 5-disubsituted-1H-pyrazolo[3,4-b]pyridines as multiacting inhibitors against microtubule and kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.46 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5631407 | — | — | 1 | 10.72 |
| CHEMBL5631455 | — | — | 1 | 9.65 |
| CHEMBL5632248 | — | — | 1 | 9.56 |
| CHEMBL5632969 | — | — | 1 | 9.53 |
| CHEMBL5633114 | — | — | 1 | 8.54 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.76 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.76 |
| CHEMBL5632037 | — | — | 1 | 7.76 |
| CHEMBL5633945 | — | — | 1 | 7.69 |
| CHEMBL5631262 | — | — | 1 | 7.67 |
| CHEMBL5633574 | — | — | 1 | 7.57 |
| CHEMBL5632051 | — | — | 1 | 7.52 |
| CHEMBL276625 | PHENSTATIN | — | 1 | 7.47 |
| CHEMBL5632675 | — | — | 1 | 7.43 |
| CHEMBL5631922 | — | — | 1 | 7.42 |
| CHEMBL5632486 | — | — | 1 | 7.27 |
| CHEMBL5632610 | — | — | 1 | 7.16 |
| CHEMBL5632115 | — | — | 1 | 7.16 |
| CHEMBL5632853 | — | — | 1 | 7.00 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 6.75 |
| CHEMBL5633472 | — | — | 1 | 6.67 |
| CHEMBL5632557 | — | — | 1 | 6.66 |
| CHEMBL5631667 | — | — | 1 | 6.53 |
| CHEMBL5634067 | — | — | 1 | 6.52 |
| CHEMBL5632744 | — | — | 1 | 6.28 |
| CHEMBL5632483 | — | — | 1 | 6.15 |
| CHEMBL5632605 | — | — | 1 | 6.09 |
| CHEMBL5632995 | — | — | 1 | 6.04 |
| CHEMBL5632519 | — | — | 1 | 5.97 |
| CHEMBL5633837 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5631407 | — | IC50 | = | 0.019 | nM | 10.72 |
| CHEMBL5631455 | — | IC50 | = | 0.222 | nM | 9.65 |
| CHEMBL5632248 | — | IC50 | = | 0.276 | nM | 9.56 |
| CHEMBL5632969 | — | IC50 | = | 0.298 | nM | 9.53 |
| CHEMBL5633114 | — | IC50 | = | 2.876 | nM | 8.54 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 17.29 | nM | 7.76 |
| CHEMBL5632037 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL5633945 | — | IC50 | = | 20.59 | nM | 7.69 |
| CHEMBL5631262 | — | IC50 | = | 21.32 | nM | 7.67 |
| CHEMBL5633574 | — | IC50 | = | 27.01 | nM | 7.57 |
| CHEMBL5632051 | — | IC50 | = | 30.19 | nM | 7.52 |
| CHEMBL276625 | PHENSTATIN | IC50 | = | 33.56 | nM | 7.47 |
| CHEMBL5632675 | — | IC50 | = | 36.71 | nM | 7.43 |
| CHEMBL5631922 | — | IC50 | = | 37.91 | nM | 7.42 |
| CHEMBL5632486 | — | IC50 | = | 53.91 | nM | 7.27 |
| CHEMBL5632610 | — | IC50 | = | 70.06 | nM | 7.16 |
| CHEMBL5632115 | — | IC50 | = | 69.39 | nM | 7.16 |
| CHEMBL5632853 | — | IC50 | = | 100.57 | nM | 7.00 |
| CHEMBL941 | IMATINIB | IC50 | = | 179.3 | nM | 6.75 |
| CHEMBL5633472 | — | IC50 | = | 214.13 | nM | 6.67 |
| CHEMBL5632557 | — | IC50 | = | 220.8 | nM | 6.66 |
| CHEMBL5631667 | — | IC50 | = | 295.83 | nM | 6.53 |
| CHEMBL5634067 | — | IC50 | = | 303.4 | nM | 6.52 |
| CHEMBL5632744 | — | IC50 | = | 519.53 | nM | 6.28 |
| CHEMBL5632483 | — | IC50 | = | 712.7 | nM | 6.15 |
| CHEMBL5632605 | — | IC50 | = | 817.97 | nM | 6.09 |
| CHEMBL5632995 | — | IC50 | = | 905.8 | nM | 6.04 |
| CHEMBL5632519 | — | IC50 | = | 1062.2 | nM | 5.97 |
| CHEMBL5633837 | — | IC50 | = | 0.008 | nM | - |