Assay Detail
Functional
CHEMBL5627784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MV4-11 cells transfected with FLT3-ITD mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 3, 5-disubsituted-1H-pyrazolo[3,4-b]pyridines as multiacting inhibitors against microtubule and kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.97 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5633837 | — | — | 1 | 9.84 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.47 |
| CHEMBL5632248 | — | — | 1 | 8.02 |
| CHEMBL5631922 | — | — | 1 | 7.94 |
| CHEMBL5633114 | — | — | 1 | 7.83 |
| CHEMBL5631407 | — | — | 1 | 7.74 |
| CHEMBL5632969 | — | — | 1 | 7.52 |
| CHEMBL5631455 | — | — | 1 | 7.20 |
| CHEMBL5632051 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5633837 | — | IC50 | = | 0.144 | nM | 9.84 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5632248 | — | IC50 | = | 9.646 | nM | 8.02 |
| CHEMBL5631922 | — | IC50 | = | 11.43 | nM | 7.94 |
| CHEMBL5633114 | — | IC50 | = | 14.76 | nM | 7.83 |
| CHEMBL5631407 | — | IC50 | = | 18.23 | nM | 7.74 |
| CHEMBL5632969 | — | IC50 | = | 30.03 | nM | 7.52 |
| CHEMBL5631455 | — | IC50 | = | 62.95 | nM | 7.20 |
| CHEMBL5632051 | — | IC50 | = | 73.33 | nM | 7.13 |